A group of scientists from the University of Alabama at Birmingham, Massachusetts General Hospital, and Vanderbilt University used 33 participants in their study They were given an acute carbohydrate load as a 294-kilocalorie shake.
After that, researchers studied the blood levels of participants for a period of six hours, trying to find reactions.
The main study is about whether this condition can alter the heart’s production of the atrial natriuretic peptide, the hormone that helps our body to eliminate excess salt and decrease blood pressure.
Scientists already know that obese people have less ANP, and when they have a high-dietary-carbohydrate load, it will suppress circulation ANP concentrations. Since they already have lower ANP in their body, this condition can only harm them.
“It is thought to be common sense that carbohydrate loading is detrimental; but the negative effects are delivered through the principal hormones, the natriuretic peptides, produced by your heart, a system that is suppressed in obese individuals,” said rid of excess salt and reduces blood pressure.
UAB’s Pankaj Arora, M.D., first author of the JACC study.
Before starting the study, all the patients were normalized on some standard study, so any dietary variability is removed.
“The carbohydrate load had a significant and notable effect on circulating ANP levels. Experimental studies suggest that it’s not good to make less ANP,” said senior author Thomas Wang, M.D., chief of the Division of Cardiovascular Medicine at Vanderbil.
Researchers also took a look at the mechanism that lower ANP levels. They can be reproduced in mice carrying the human ANP gene. A molecule is known as miR-425, which was described as an inhibitor of ANP production. By stimulating a transcription factor the glucose makes more miR-425.
“Moving forward, we will focus on dissecting the pathophysiological link between miR-425-ANP axis in obesity and diabetes, which can translate into favorable effects on cardiometabolic health in this population,” Arora stated.